Fire Retardants in Toddlers and Their Mothers

Levels Three Times Higher in Toddlers Than Moms

September 4, 2008

Fire Retardants in Toddlers and Their Mothers: References

ACC. 2002. Voluntary Children's Chemical Evaluation Program: Data Summary, Decabromodiphenyl Ether (DBDPO): American Chemistry Council's Brominated Flame Retardant Industry Panel (BFRIP). Available:

Ahn, MY, Filley TR, Jafvert CT, Nies L, Hua I, Bezares-Cruz J. 2006. Photodegradation of decabromodiphenyl ether adsorbed onto clay minerals, metal oxides, and sediment. Environmental Science & Technology 40(1):215-220.

Allen JG, McClean MD, Stapleton HM, Nelson JW, Webster TF. 2007. Personal exposure to polybrominated diphenyl ethers (PBDEs) in residential indoor air. Environ Sci Technol 41(13): 4574-4579.

Allen JG, McClean MD, Stapleton HM, Webster TF. 2008. Linking PBDEs in house dust to consumer products using X-ray fluorescence. Environ Sci Technol 42(11): 4222-8.

Athanasiadou M, Cuadra SN, Marsh G, Bergman A, Jakobsson K. 2008. Polybrominated Diphenyl Ethers (PBDEs) and Bioaccumulative Hydroxylated PBDE Metabolites in Young Humans from Managua. Environ Health Perspect 116(3): 400-08. ATSDR. 2004. Toxicological Profile for Polybrominated Biphenyls and Polybrominated diphenyl ethers. Atlanta, GA: Agency for Toxics Substances and Disease Registry. Available: [Accessed 2008].

Betts K. 2008a. Spending time in vehicles can increase PBDE exposure. Environmental Science and Technology. March 26, 2008.

Betts K. 2008b. European court bans widely used flame retardant. 2008. Environmental Science and Technology: Policy news. April 30, 2008.

Betts K. 2008c. New flame retardants detected in indoor and outdoor environments. Environmental Science and Technology: Policy news. August 6, 2008. Available online at:

Bi X, Thomas GO, Jones KC, Qu W, Sheng G, Martin FL, et al. 2007. Exposure of electronics dismantling workers to polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in South China. Environ Sci Technol 41(16): 5647-53.

Birnbaum LS, Cohen Hubal EA. 2006. Polybrominated diphenyl ethers: a case study for using biomonitoring data to address risk assessment questions. Environ Health Perspect 114(11): 1770-5.

Blanck HM, Marcus M, Hertzberg V, Tolbert PE, Rubin C, Henderson AK, et al. 2000. Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort. Environ Health Perspect 108(2): 147-52.

Blanck HM, Marcus M, Rubin C, Tolbert PE, Hertzberg VS, Henderson AK, et al. 2002. Growth in girls exposed in utero and postnatally to polybrominated biphenyls and polychlorinated biphenyls. Epidemiology 13(2): 205-10.

Bloom MS, Buck Louis GM, Schisterman EF, Liu A, Kostyniak PJ. 2007. Maternal serum polychlorinated biphenyl concentrations across critical windows of human development. Environ Health Perspect 115(9): 1320-4.

Boersma ER, Lanting CI. 2000. Environmental exposure to polychlorinated biphenyls (PCBs) and dioxins. Consequences for longterm neurological and cognitive development of the child lactation. Adv Exp Med Biol 478: 271-287.

Branchi I, Capone F, Alleva E, Costa LG. 2003. Polybrominated diphenyl ethers: neurobehavioral effects following developmental exposure. Neurotoxicology 24(3): 449-62. BSEF (Bromine Science and Environmental Forum). 2006.

EEN Report: Assessing DecaBDE Debromination in the Environment. May 31, 2006. last viewed August 2008.

BSEF (Bromine Science and Environmental Forum). 2006. Fact Sheet: Applications of Deca-BDE. Available at: last viewed August 2008.

BSEF (Bromine Science and Environmental Forum). 2007. Fact Sheet: Deca-BDE (Decabromodiphenyl Ether). last viewed August 2008.

CDC. 2007. 2003-2004 Laboratory files, Lab 28 Polybrominated diphenyl ethers. Available: downloaded January 2008.

Christensen JR, MacDuffee M, Macdonald RW, Whiticar M, Ross PS. 2005. Persistent organic pollutants in British Columbia grizzly bears: consequence of divergent diets. Environ Sci Technol 39(18): 6952-60.

Curtis K. 2007. A growing trend: government action on DecaBDE. Presentation courtesy of Kathy Curtis, Policy Director, Clean New York and PBDE Strategic Collaboration Campaign Coordinator, Environmental Health Fund. ERC Documents/Meeting Documents/14 February 2008/Presentations/14 Feb 2008 Curtis - Flame Retardant Actions.pdf

Dorea JG. 2006. Maternal exposure to endocrine-active substances and breastfeeding. Am J Perinatol 23(5): 305-12. Environment California. 2004. Body of Evidence: New science in the debate over toxic flame retardants and our health. Available online at:

Environmental Working Group. 2003. Mothers' Milk: Record levels of toxic fire retardants found in American mothers' breast milk. Washington, DC.

Environmental Working Group. 2004. In the Dust. Washington, DC. Environmental Working Group. 2005. Body Burden: The Pollution in Newborns. Washington, DC. EPA. 2005. Voluntary Children's Chemical Evaluation Program: data needs decision document of Decabromodiphenyl Ether (DBDPO). Washington, DC:

Environmental Protection Agency. EPA. 2007. Funding opportunities- children’s vulnerability to toxic substances. EPA. 2008a. Reference Dose for PBDE-47. Integrated Risk Information System. last viewed July 2008.

EPA. 2008b. Reference Dose for PBDE-99. Integrated Risk Information System. last viewed July 2008.

EPA. 2008c. Reference Dose for PBDE-153. Integrated Risk Information System. last viewed July 2008.

EPA. 2008d. Reference Dose for PBDE-209. Integrated Risk Information System. last viewed July 2008.

EPA. 2008e. Lead in paint, dust, and soil: basic information. Available online at: EPA. 2008f. America’s children and the environment: childhood illnesses. Available online at:

Eriksson P, Jakobsson E, Fredriksson A. 2001. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environ Health Perspect 109(9): 903-908.

Eskenazi B, Marks AR, Bradman A, Fenster L, Johnson C, Barr DB, et al. 2006. In Utero Exposure to Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) and Neurodevelopment Among Young Mexican American Children. Pediatrics 118(233-241).

Fängstrom B, Hovander L, Bignert A, Athanassiadis I, Linderholm L, Grandjean P, et al. 2005. Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later. Environ Sci Technol 39(24): 9457-63.

Fängstrom B, Athanassiadis I, Odsjo T, Noren K, Bergman Å. 2008. Temporal trends of polybrominated diphenyl ethers and hexabromocyclododecane in milk from Stockholm mothers, 1980-2004. Mol Nutr Food Res 52(2): 187-93.

Fischer D, Hooper K, Athanasiadou M, Athanassiadis I, Bergman A. 2006. Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study. Environ Health Perspect 114(10): 1581-4.

Gomara B, Herrero L, Ramos JJ, Mateo JR, Fernandez MA, Garcia JF, et al. 2007. Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain. Environ Sci Technol 41(20): 6961-8.

Greenpeace. 2008. Guide to Greener Electronics-8th edition. June 25, 2008. Available at:, viewed Aug. 13, 2008.

He JZ, Robrock KR, Alvarez-Cohen L. 2006. Microbial reductive debromination of polybrominated diphenyl ethers (PBDEs). Environmental Science & Technology 40(14):4429-4434.

Herbstman JB, Sjodin A, Apelberg BJ, Witter FR, Patterson DG, Halden RU, et al. 2007. Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population. Environ Health Perspect 115(12): 1794-800.

Hooper K, McDonald TA. 2000. The PBDEs: An emerging environmental challenge and another reason for breast-milk monitoring programs. Environmental Health Perspectives 108(5):387-92.

Hooper K, She J, Sharp M, Chow J, Jewell N, Gephart R, et al. 2007. Depuration of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk from California first-time mothers (primiparae). Environ Health Perspect 115(9): 1271-5.

Huwe JK, Smith DJ. 2007. Accumulation, whole-body depletion, and debromination of decabromodiphenyl ether in male sprague-dawley rats following dietary exposure. Environ Sci Technol 41(7): 2371-7.

Illinois EPA. 2007. Report on Alternatives to the Flame Retardant DecaBDE: Evaluation of Toxicity, Availability, Affordability, and Fire Safety Issues., last viewed September 2008.

Jacobson JL, Jacobson SW. 2002. Breast-feeding and gender as moderators of teratogenic effects on cognitive development. Neurotoxicol Teratol 24(3): 349-58.

Jensen TK, Grandjean P, Jorgensen EB, White RF, Debes F, Weihe P. 2005. Effects of breast feeding on neuropsychological development in a community with methylmercury exposure from seafood. J Expo Anal Environ Epidemiol 15(5): 423-430.

Jones-Otazo HA, Clarke JP, Diamond ML, Archbold JA, Ferguson G, Harner T, et al. 2005. Is house dust the missing exposure pathway for PBDEs? An analysis of the urban fate and human exposure to PBDEs. Environ Sci Technol 39(14): 5121-30.

Jorissen J. 2007. Literature review. Outcomes associated with postnatal exposure to polychlorinated biphenyls (PCBs) via breast milk. Adv Neonatal Care 7(5): 230-7.

Kajiwara N, Noma Y, Takigami H. 2008. Photolysis studies of technical decabromodiphenyl ether (DecaBDE) and ethane (DeBDethane) in plastics under natural sunlight. Environ Sci Technol 42(12): 4404-9.

Kierkegaard A, Balk L, Tjärnlund U, de Wit CA, Jansson B. 1999. Dietary uptake and biological effects of decabromodiphenyl ether in Rainbow trout (Oncorhynchus mykiss). Environ Sci Technol 33: 1612-17.

Koopman-Esseboom C, Weisglas-Kuperus N, de Ridder MA, Van der Paauw CG, Tuinstra LG, Sauer PJ. 1996. Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development. Pediatrics 97(5): 700-6.

Kuriyama SN, Talsness CE, Grote K, Chahoud I. 2005. Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring. Environ Health Perspect 113(2): 149-54.

La Guardia MJ, Hale RC, Harvey E. 2006. Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures. Environ Sci Technol 40(20): 6247-54.

La Guardia MJ, Hale RC, Harvey E. 2007. Evidence of debromination of decabromodiphenyl ether (BDE-209) in biota from a wastewater receiving stream. Environ Sci Technol 41(19): 6663-70.

LaKind JS, Berlin CM, Naiman DQ. 2001. Infant exposure to chemicals in breast milk in the United States: what we need to learn from a breast milk monitoring program. Environ Health Perspect 109(1): 75-88.

Landrigan PJ, Carlson JE. 1995. Environmental policy and children’s health. Critical Issues for Children and Youths 5(2): 34-52. Lorber M. 2008. Exposure of Americans to polybrominated diphenyl ethers. J Expo Sci Environ Epidemiol 18(1): 2-19.

Main KM, Kiviranta H, Virtanen HE, Sundqvist E, Tuomisto JT, Tuomisto J, et al. 2007. Flame retardants in placenta and breast milk and cryptorchidism in newborn boys. Environ Health Perspect 115(10): 1519-26.

Maine Department of Environmental Protection and Maine Center for Disease Control and Protection. 2007. Brominated flame retardants: third annual report to the Maine Legislature. Available online at: McDonald, TA. 2005. Polybrominated diphenylether levels among United States residents: daily intake and risk of harm to the developing brain and reproductive organs. Integrated Environmental Assessment and Management 1(4): 745-55.

Meironyte D, Norén K, Bergman A. 1999. Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972-1997. J Toxicol Environ Health A 58(6): 329-41. Minnesota Pollution Control Agency. 2008. Decabromodiphenyl Ether. A Report to the Minnesota Legislature. January 15, 2008,

Moya J, Bearer CF, Etzel RA. 2004. Children’s behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics 113(4): 996-1006. National Caucus of Environmental Legislators. 2008. Enacted and introduced PBDE legislation. Available online at National Research Council. 1993. Pesticides in the diets of infants and children. National Academy Press, Washington, D.C.

National Academy of Science (NAS). 2000. Toxicological Risks of Selected Flame-Retardant Chemicals. National Academy Press. Washington, DC. Available at:

Norén K, Meironyte D. 2000. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40(9-11): 1111-23.

Qu W, Bi X, Sheng G, Lu S, Fu J, Yuan J, et al. 2007. Exposure to polybrominated diphenyl ethers among workers at an electronic waste dismantling region in Guangdong, China. Environ Int 33(8): 1029-34.

Ribas-Fito N, Cardo E, Sala M, Eulalia de Muga M, Mazon C, Verdu A, et al. 2003. Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants. Pediatrics 111(5 Pt 1): e580-5.

Rice DC, Reeve EA, Herlihy A, Zoeller RT, Thompson WD, Markowski VP. 2007. Developmental delays and locomotor activity in the C57BL6/J mouse following neonatal exposure to the fully-brominated PBDE, decabromodiphenyl ether. Neurotoxicol Teratol 29(4): 511-20.

Schecter A, Papke O, Harris TR, Tung KC, Musumba A, Olson J, et al. 2006. Polybrominated diphenyl ether (PBDE) levels in an expanded market basket survey of U.S. food and estimated PBDE dietary intake by age and sex. Environ Health Perspect 114(10): 1515-20. Schwartz J. 1994. Societal benefits of reducing lead exposure. Environ Res. 1994 Jul;66(1):105-24.

Sexton K, Adgate JL, Fredrickson AL, Ryan AD, Needham LL, Ashley DL. 2006. Using biologic markers in blood to assess exposure to multiple environmental chemicals for inner-city children 3-6 years of age. Environ Health Perspect 114(3): 453-459.

Sjödin A, Wong L-Y, Jones RS, Park A, Zhang Y, Hodge C, ., et al. 2008. Serum Concentrations of Polybrominated Diphenyl Ethers (PBDEs) and Polybrominated Biphenyl (PBB) in the United States Population: 2003–2004. Environ Sci Technol 42(4): 1377-84.

Stapleton HM, Dodder NG, Offenberg JH, Schantz MM, Wise SA. 2005. Polybrominated diphenyl ethers in house dust and clothes dryer lint. Environ Sci Technol 39(4): 925-31.

Stapleton H. 2006. Brominated Flame Retardants: Summary of Scientifi Studies on Accumulation and Debromination of DecaBDE. December 11, 2006.

Stapleton H, Dodder N. 2007. Photodegradation of Decabromodiphenyl Ether in House Dust by Natural Sunlight. Environ Toxicol Chem: 1.

Stapleton HM, Kelly SM, Allen JG, McClean MD, Webster TF. 2008. Measurement of Polybrominated Diphenyl Ethers on Hand Wipes: Estimating Exposure from Hand-to-Mouth Contact. ES&T 42(3329-3334).

Sunyer J, Torrent M, Munoz-Ortiz L, Ribas-Fito N, Carrizo D, Grimalt J, et al. 2005. Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children. Environ Health Perspect 113(12): 1787-90.

Sunyer J, Torrent M, Garcia-Esteban R, Ribas-Fito N, Carrizo D, Romieu I, et al. 2006. Early exposure to dichlorodiphenyldichloroethylene, breastfeeding and asthma at age six. Clin Exp Allergy 36(10): 1236-41.

Talsness CE, Shakibaei M, Kuriyama SN, Grande SW, Sterner-Kock A, Schnitker P, et al. 2005. Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant. Toxicol Lett 157(3): 189-202.

Thomsen C, Haug LS, Leknes H, Lundanes E, Becher G, Lindstrom G. 2002. Comparing electron ionization high-resolution and electron capture low-resolution mass spectrometric determination of polybrominated diphenyl ethers in plasma, serum and milk. Chemosphere 46(5): 641-8.

Thuresson K, Höglund P, Hagmar L, Sjödin A, Bergman A, Jakobsson K. 2006. Apparent Half-Lives of Hepta- to Decabrominated Diphenyl Ethers in Human Serum as Determined in Occupationally Exposed Workers. Environmental Health Perspectives 114(2)176-181.

Toms L-M, Harden F, Paepke O, Hobson P, Ryan JJ, Mueller J. 2008a. Higher Accumulation of Polybrominated Diphenyl Ethers in Infants Than in Adults. Environmental Science and Technology. Advanced copy, article posted online: August 29, 2008. 10.1021/es800719v

Toms L-M, Anderson S, Park A, Jones R, Harden F, Hobson P, Needham LL, Mueller JF, Sjödin A. 2008b. Concentrations of Polybrominated Diphenyl Ethers in Pooled Serum from Australia. Poster presented at Fifth International Workshop on Brominated Flame Retardants, British Columbia. Canada. June 3 - 4, 2008.

Tulve NS, Suggs JC, McCurdy T, Hubal EA, Moya J. 2002. Frequency of mouthing behavior in young children. J. Exposure Anal. Environ. Epidemiol. 2002, 12 (4), 259–264.

Turyk ME, Persky VW, Imm P, Knobeloch L, Chatterton R, Anderson HA. 2008. Hormone disruption by PBDEs in adult male sport fish consumers. Environmental Health Perspectives, epub July 24, 2008.

Van den Steen E, Covaci A, Jaspers VL, Dauwe T, Voorspoels S, Eens M, et al. 2007. Accumulation, tissue-specific distribution and debromination of decabromodiphenyl ether (BDE 209) in European starlings (Sturnus vulgaris). Environ Pollut 148(2): 648-53.

Van der Ven LT, van de Kuil T, Leonards PE, Slob W, Canton RF, Germer S, et al. 2008. A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE). Toxicol Lett 179(1): 6-14.

Viberg H, Fredriksson A, Eriksson P. 2003a. Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicol Appl Pharmacol 192(2): 95-106.

Viberg H, Fredriksson A, Jakobsson E, Orn U, Eriksson P. 2003b. Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development. Toxicol Sci 76(1): 112-120.

Viberg H, Fredriksson A, Eriksson P. 2007. Changes in spontaneous behaviour and altered response to nicotine in the adult rat, after neonatal exposure to the brominated flame retardant, decabrominated diphenyl ether (PBDE 209). Neurotoxicology 28(1): 136-42.

Voorspoels S, Covaci A, Lepom P, Escutenaire S, Schepens P. 2006. Remarkable findings concerning PBDEs in the terrestrial top-predator red fox (Vulpes vulpes). Environ Sci Technol 40(9): 2937-43.

Voorspoels S, Covaci A, Jaspers VL, Neels H, Schepens P. 2007. Biomagnification of PBDEs in three small terrestrial food chains. Environ Sci Technol 41(2): 411-6. Washington State Department of Ecology and Department of Health. 2006. Washington State Polybrominated Diphenyl Ether (PBDE) Chemical Action Plan: Final Plan. January 19, 2006. Department of Ecology Publication No. 05-07-048, Department of Health Publication No. 334-079

Wu N, Herrmann T, Paepke O, Tickner J, Hale R, Harvey LE, et al. 2007. Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations. Environ Sci Technol 41(5): 1584-9.